Selected Polymorphisms, Fatty Acid Regulation and the Metabolic Syndrome in Overweight American Indian Adolescents aged 15 to 25 Years Old

Abstract:

The purpose of this study is to look at common rearrangements in DNA (the substance of heredity) of certain genes (coding units passed on from parents to children), which may increase a person’s risk of developing diabetes, high fats in the blood causing blockage of the arteries, abnormal liver functions causing liver disease, clotting problems, and high blood pressure later in life.  When the problems cluster together in the same person it is called the “metabolic syndrome”.  The genes that will be studied are involved in regulating the fats in the blood, clotting, inflammation, and blood vessel function.  By finding markers of future disease we may be able to prevent disease from occurring.

Participant Inclusion Criteria:

1. American Indian

2. Ages 15 - 25

3. Overweight

Participant Compensation: Yes

Contact Information:

Lancer Stephens, Special Populations Unit Executive Director. (405) 271-4272 x 42732 or lancer-stephens@ouhsc.edu When inquiring, please mention the American Indian Adolescent study.

Please note: Subjects have the choice of taking part in the project at the University of Oklahoma Health Sciences Center or at the Oklahoma City Indian Clinic