Christopher E. Aston

Biostatistics/Informatics Core Director,

General Clinical Research Center

Chris-Aston@ouhsc.edu

Research Interests:

Genetics, Endocrinology, Special Populations Health Disparities

Education:

1982, BS, University of Sydney, Sydney, Australia

1986, PhD, Australian National University, Canberra, Australia

1987, Post Doc., Memorial Sloan-Kettering Cancer Center, New York, NY

Recent Publications:

Amann ST, Gates Jr LK, Aston CE, Pandya A, Whitcomb DC: Expression and penetrance of the hereditary pancreatitis phenotype in monozygotic twins. Gut 48:542-7, 2001.

Applebaum-Shapiro SE, Peters JA, O'Connell JA, Aston CE, Whitcomb DC: Motivations and concerns of patients with access to genetic testing for hereditary pancreatitis. Am J Gastroenterol 96:1610-7, 2001.

DePrince KM, McGarvey ST, McAllister AE, Bausserman L, Aston CE, Ferrell RE, Kamboh MI: Genetic effect of two Apo(a) repeat polymorphisms (Kringle 4 and Pentanucleotide repeats) on plasma Lp(a) levels in American Samoans. Hum Biol 73:91-104, 2001.

Jupe ER, Badgett AA, Neas BR, Craft MA, Mitchell DS, Resta R, Mulvihill JJ, Aston CE, Thompson LF: A single nucleotide polymorphism in the prohibitin 3' untranslated region is a marker of breast cancer susceptibility. Lancet 357:1588-9, 2001.

Kimm SYS, Glynn NW, Aston CE, Poehlman ET, Daniels SR: Effects of race, cigarette smoking and use of contraceptive medications on resting energy expenditure in young women. Am J Epid 154:718-724, 2001.

Nath S, Kelly J, Namjou B, Lam T, Bruner G, Scofield R, Aston CE, Harley JB: Evidence for a susceptibility gene (SLEV1) on chromosome 17p13 for vitiligo related systemic lupus erythematosus families Am J Hum Genet 69: 1401-6, 2001.

Witchel SF, Smith R, Tomboc M, Aston CE: Candidate gene analysis in premature pubarche and adolescent hyperandrogenism. Fertil Steril 75:724-730, 2001.

Witchel SF, White C, Siegel ME, Aston CE: Inconsistent effects of the Proline12 →Alanine (P12A) variant of the peroxisome proliferator-activated receptor-?2 (PPAR-?2) gene on body mass index in children and adolescent girls. Fertil Steril 76:741-7, 2001.

Ibáñez L, Marcos MV, Potau N, White C, Aston CE, Witchel SF: Increased frequency of the G972R variant of the insulin receptor substrate (IRS-1) among girls with a history of precocious pubarche (PP). Fertil Steril 78:1288-93, 2002.

Kelly JA, Thompson K, Kilpatrick J, Lam T, Nath SK, Gray-McGuire C, Reid J, Namjou B, Aston CE, Bruner GR, Scofield RH, Harley JB: Evidence for a susceptibility gene (SLEH1) on chromosome 11q14 for systemic lupus erythematosus (SLE) families with hemolytic anemia. Proc Natl Acad Sci USA 99:11766-71, 2002.

Kimm SYS, Glynn NW, Aston CE, Damcott CM, Poehlman ET, Daniels SR, Ferrell RE: Racial differences in the relationship between uncoupling protein genes and resting energy expenditure. Am J Clin Nutr 75:714-9, 2002.

Nath SK, Kelly JA, Reid J, Lam T, Gray-McGuire C, Namjou B, Aston CE, Harley JB: SLEB3 in Systemic Lupus Erythematosus (SLE) is strongly related to SLE families ascertained through neuropsychiatric manifestations. Hum Genet 111:54-8, 2002.

Ouyang Y-B, Crawley JTB, Aston CE, Moore KL: Reduced body weight and increased post-implantation fetal death in tyrosylpotein sulfotransferase-1 deficient mice. J Biol Chem 8(6), 2002.

Sanders EB, Aston CE, Ferrell RE, Witchel SF: Inter- and intra-familial variability in premature pubarche and polycystic ovary syndrome. Fertil Steril 78:473-8, 2002.

Aston CE: Reply to AP Polednak (Letter to the Editor). Am J Clin Nutr 77:1528, 2003.

Astrom K, Cohen JE, Willett-Brozick JE, Aston CE, Baysal BE: Altitude is a phenotypic modifier in hereditary paraganglioma type 1: evidence for an oxygen-sensing defect. Human Genetics 113:228-37, 2003.

Foster MW, Aston CE: A practice approach for identifying previously unsuspected environmental contributors to SLE and other complex diseases. Env Health Perspectives 111(4):593-7, 2003.        

Quintero-Del-Rio AI, Kelly JA, Phillip Garriott C, Hutchings DC, Frank SG, Aston CE, Harley JB: SLEN2 (2q34-35) and SLEN1 (10q22.3) Replication in Systemic Lupus Erythematosus Stratified by Nephritis. Am J Hum Genet 75:346-348, 2004.

Aston CE, Ralph DA, Lalo DP, Manjeshwar S, Gramling BA, DeFreese DC, West AD, Branam DE, Thompson LF, Craft MA, Mitchell DS, Shimasaki CD, Venkateswarlu K, Mulvihill JJ, Jupe ER: Oligogenic combinations associated with breast cancer risk in women under 53 years of age. Hum Genet 116: 208-221, 2005.

Kimm SYS, Glynn NW, Obarzanek E, Aston CE, Poehlman ET, Daniels SR: Demographic and psychosocial correlates of mis-reporting of energy intake in a biracial cohort of young women. Obesity Res. (in press), 2005.

Witchel SF, Kahsar-Miller M, Aston CE, White C, Azziz R (2004) Prevalence of CYP21 Mutations and IRS-1 Variant among Women with the Polycystic Ovary Syndrome and Adrenal Androgen Excess. Fertil Steril 83: 371-375, 2005.