Lyons 0121

About the GCRC Investigator Information Applications & Forms Related Links Notice of Privacy Practices and HIPAA complaint form

: HOME / active protocol list, lyons 0121

Biochemical Markers of Inflammation, Oxidative Stress and Cardiovascular Risk in Adult Patients With Lower Extremity Atherosclerotic Disease With Diabetes vs Without Diabetes: a Cross-Sectional Study

Principal Investigator: Timothy Lyons, MD, FRCP

Abstract:

Objective: To gather data on 'the differences in disease-related biochemical markers in adult patients with lower extremity atherosclerotic disease (LEAD) with type 2 diabetes vs non-diabetecs' to estimate variations in proposed measures and sample sizes of the larger planned study.

Specific Aims:

1. In atheromatous plaque obtained from lower extremity arteries of adult patients with type 2 diabetes vs non-diabetics, determine the differences among tissue levels and types of biochemical markers, modulators and receptors of inflammation and oxidative stress (eg, nitric oxide synthase and coclooxygenase), and the histologic architecture;

2. In blood samples of adult patients with LEAD with type 2 diabetes vs non-diabetics, determine the differences among levels and types of biochemical markers, modulators and receptors of inflammation and oxidative stress (eg, nitric oxide synthase and cyclooxygenase) in leukocytes and platelets, and the quantities of 'collagen and thrombin' activated (COAT) platelets;

3. In the serum and urine of adult patients with LEAD with type 2 diabetes with LEAD with type 2 diabetes vs non-diabetics, determine the differences among levels of biochemical markers of inflammation, oxidative stress (eg, CRP, OL-6, TNF-a, CAP-3), and cardiovascular risk (eg, A1C, lipid profile, urine microalbumin).

Participant Inclusion Criteria:

Participant Compensation:

Contact Information:

Muhammad Firdaus, MD (405) 271-5896

About the GCRC Investigator Information Applications & Forms Related Links Online Application

OUHSC HOME / SEARCH

General Clinical Research Center
O'Donoghue Research Building Suite 150
1122 N.E. 13th St.
Oklahoma City, Oklahoma 73104
Phone: (405)271-4272
E-mail: julie-traylor@ouhsc.edu

This web site Built and Maintained by the Information Design Group a department of the University of Oklahoma Health Sciences Center.

Every effort will be made to update the information contained on these pages as necessary. However, it is the responsibility of the user to determine that he or she is relying on the most current version of any particular information. Any questions about the material should be directed to the referenced office or department.