Effects of Fluid Load on Urine Characteristics

Pricipal Investigator: Arvind K. Chaturvedi, Ph.D. Biochemistry Research, Toxicology and Accident Research Laboratory (AAM-610), FAA Civil Aerospace Medical Institute

 

Abstract:

A focused scientific study to establish changes in typical urine characteristics and to correlate those changes with the fluid type and amount intake, body mass index (BMI), metabolic rate, body weight, and other related parameters. In this study, collected urine samples will be tested for their specific gravity and osmolality; and creatinine, nitrite, chromium ion, and iodide levels. Urine samples WILL NOT BE TESTED FOR ILLEGAL SUBSTANCES.

Specific Aims:

Findings from the study will be the first step in establishing the normal distribution of the tested urine parameters under the proposed fluid intakes for this age range. Such information would be utilized in scientifically and correctly interpreting the results of urine validity testing of samples collected under the workplace drug abatement programs. As these studies progress, the testing results should be able to withstand judicial and scientific scrutiny, and thereby assist in enhancing aviation safety without accusing an innocent urine sample donor.

Participant Inclusion Criteria:

The subject population of this pilot study will consist of a convenience sample of 24 healthy volunteers between the ages of 25 and 35. Twelve of these subjects will be male and twelve will be female. To decrease variability of body composition measures at this initial investigative stage, participants will be limited to those with a body mass index (BMI) of less than 32. To control for the influence of fluid shifts associated with menstrual cycles, studies will be performed on women between day 6 and 15 of their menstrual cycle.

To prevent erroneous errors in interpreting data, persons reporting thyroid or cardiac disease or eating disorders will be excluded from participation.

Participant Compensation:

Yes

Contact Information:

Misti Leyva, GCRC Bionutrition Director. (405) 271-4272 x 42731 or misti-leyva@ouhsc.edu When inquiring, please mention the FAA study being conducted at the General Clinical Research Center

 

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